| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholine receptor subunit epsilon |
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| Ligand | BDBM50516965 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1867225 (CHEMBL4368200) |
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| IC50 | 3060±n/a nM |
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| Citation |  Xu, M; Peng, Y; Zhu, L; Wang, S; Ji, J; Rakesh, KP Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships. Eur J Med Chem180:656-672 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholine receptor subunit epsilon |
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| Name: | Acetylcholine receptor subunit epsilon |
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| Synonyms: | ACHE_HUMAN | ACHRE | Acetylcholine receptor protein epsilon chain | CHRNE | Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54686.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_431077 |
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| Residue: | 493 |
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| Sequence: | MARAPLGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNL
ISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQF
GVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTF
AVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKP
LFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLS
VPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPP
EAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEV
RCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFN
RVPDLPYAPCIQP
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| BDBM50516965 |
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| n/a |
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| Name | BDBM50516965 |
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| Synonyms: | CHEMBL4458943 |
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| Type | Small organic molecule |
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| Emp. Form. | C42H40FN3O5S |
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| Mol. Mass. | 717.848 |
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| SMILES | Fc1ccccc1-c1n[nH]c(=S)n1[C@H]1[C@H](OCc2ccccc2)O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 |r| |
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| Structure | 
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