| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM50069447 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1867543 (CHEMBL4368518) |
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| Ki | 52±n/a nM |
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| Citation |  ?elaszczyk, D; Jakubczyk, M; Pytka, K; Rapacz, A; Walczak, M; Janiszewska, P; Pa?czyk, K; ?mudzki, P; S?oczy?ska, K; Marona, H; Waszkielewicz, AM Design, synthesis and evaluation of activity and pharmacokinetic profile of new derivatives of xanthone and piperazine in the central nervous system. Bioorg Med Chem Lett29:0 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46445.29 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Binding assays were performed using rat hippocampal membranes. |
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| Residue: | 422 |
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| Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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| BDBM50069447 |
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| n/a |
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| Name | BDBM50069447 |
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| Synonyms: | 1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-one | 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one | CHEMBL623 | NEFAZODONE | US9138393, Nefazodone HCl | US9144538, Nefazodone HCl |
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| Type | Small organic molecule |
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| Emp. Form. | C25H32ClN5O2 |
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| Mol. Mass. | 470.007 |
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| SMILES | CCc1nn(CCCN2CCN(CC2)c2cccc(Cl)c2)c(=O)n1CCOc1ccccc1 |
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| Structure | 
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