| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk2 |
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| Ligand | BDBM50517776 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1869709 (CHEMBL4370775) |
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| IC50 | 1700±n/a nM |
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| Citation |  Abdelbaset, MS; Abdel-Aziz, M; Ramadan, M; Abdelrahman, MH; Abbas Bukhari, SN; Ali, TFS; Abuo-Rahma, GEA Discovery of novel thienoquinoline-2-carboxamide chalcone derivatives as antiproliferative EGFR tyrosine kinase inhibitors. Bioorg Med Chem27:1076-1086 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Chk2 |
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| Name: | Serine/threonine-protein kinase Chk2 |
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| Synonyms: | CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | RAD53 | Serine/threonine-protein kinase Chek2 | Serine/threonine-protein kinase Chk1/2 |
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| Type: | Protein |
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| Mol. Mass.: | 60908.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O96017 |
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| Residue: | 543 |
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| Sequence: | MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE
DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC
LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA
LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
AVL
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| BDBM50517776 |
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| n/a |
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| Name | BDBM50517776 |
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| Synonyms: | CHEMBL4449599 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16N4S |
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| Mol. Mass. | 308.401 |
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| SMILES | CCCCNc1ncnc2c3cc4ccccc4nc3sc12 |
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| Structure | 
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