Reaction Details |
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Target | Decaprenylphosphoryl-beta-D-ribose oxidase |
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Ligand | BDBM50517944 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1870163 (CHEMBL4371330) |
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IC50 | 120±n/a nM |
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Citation | Chikhale, RV; Barmade, MA; Murumkar, PR; Yadav, MR Overview of the Development of DprE1 Inhibitors for Combating the Menace of Tuberculosis. J Med Chem61:8563-8593 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Decaprenylphosphoryl-beta-D-ribose oxidase |
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Name: | Decaprenylphosphoryl-beta-D-ribose oxidase |
Synonyms: | DPRE1_MYCTU | Decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase | Decaprenylphosphoryl-beta-D-ribose 2-epimerase flavoprotein subunit | Decaprenylphosphoryl-beta-D-ribose oxidase | FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase | dprE1 |
Type: | PROTEIN |
Mol. Mass.: | 50167.60 |
Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Description: | ChEMBL_116793 |
Residue: | 461 |
Sequence: | MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSY
GDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQ
VTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRHLTPTGEDAELFWATVGGNGL
TGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKL
GRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKS
GTYRGKVQNLTQFYHPLDMFGEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHY
SFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFVSELDRRVLEFGGRLYTAKDS
RTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL
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BDBM50517944 |
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n/a |
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Name | BDBM50517944 |
Synonyms: | CHEMBL4576609 |
Type | Small organic molecule |
Emp. Form. | C18H11F6N3O2 |
Mol. Mass. | 415.2893 |
SMILES | OC(=O)c1nc2ccc(cc2nc1NCc1ccc(cc1)C(F)(F)F)C(F)(F)F |
Structure |
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