| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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| Ligand | BDBM50518066 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1870503 (CHEMBL4371670) |
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| IC50 | 0.380000±n/a nM |
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| Citation |  Devasthale, P; Cheng, D Monoacylglycerol Acyltransferase 2 (MGAT2) Inhibitors for the Treatment of Metabolic Diseases and Nonalcoholic Steatohepatitis (NASH). J Med Chem61:9879-9888 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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| Name: | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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| Synonyms: | 2.4.1.143 | Beta-1,2-N-acetylglucosaminyltransferase II | GNT-II | GlcNAc-T II | MGAT2 | MGAT2_HUMAN | Mannoside acetylglucosaminyltransferase 2 | Monoacylglycerol acyltransferase 2 (MGAT2) | Monoacylglycerol acyltransferase type 2 (h-MGAT2) | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II | h-MGAT2 (human monoacylglycerol acyltransferase type 2) |
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| Type: | n/a |
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| Mol. Mass.: | 51567.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q10469 |
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| Residue: | 447 |
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| Sequence: | MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKNEALAPPLLDAEPARGAGGRGGDHPSV
AVGIRRVSNVSAASLVPAVPQPEADNLTLRYRSLVYQLNFDQTLRNVDKAGTWAPRELVL
VVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAGVNFCPVLQVFFPFS
IQLYPNEFPGSDPRDCPRDLPKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHF
VWERVKILRDYAGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTYSASRSF
YGMADKVDVKTWKSTEHNMGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTVSCLPK
FWKVLVPQIPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNNNKQYMFPETLTISEKFTVV
AISPPRKNGGWGDIRDHELCKSYRRLQ
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| BDBM50518066 |
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| n/a |
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| Name | BDBM50518066 |
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| Synonyms: | CHEMBL4572662 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H32N4O2S |
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| Mol. Mass. | 500.655 |
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| SMILES | O=C(CCNC1Cc2ccccc2C1)N1CCc2nc(SC3CCC3)n(-c3ccccc3)c(=O)c2C1 |
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| Structure | 
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