| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-C chemokine receptor type 1 |
|---|
| Ligand | BDBM50518078 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1870528 (CHEMBL4371695) |
|---|
| Ki | 22±n/a nM |
|---|
| Citation |  Ortiz Zacarķas, NV; van Veldhoven, JPD; Portner, L; van Spronsen, E; Ullo, S; Veenhuizen, M; van der Velden, WJC; Zweemer, AJM; Kreekel, RM; Oenema, K; Lenselink, EB; Heitman, LH; IJzerman, AP Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2. J Med Chem61:9146-9161 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-C chemokine receptor type 1 |
|---|
| Name: | C-C chemokine receptor type 1 |
|---|
| Synonyms: | C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41180.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P32246 |
|---|
| Residue: | 355 |
|---|
| Sequence: | METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
|
|
|
|---|
| BDBM50518078 |
|---|
| n/a |
|---|
| Name | BDBM50518078 |
|---|
| Synonyms: | CHEMBL4569870 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H29NO3 |
|---|
| Mol. Mass. | 355.4706 |
|---|
| SMILES | Cc1ccc(cc1)N1C(C2CCCCC2)C(C(=O)C(C)(C)C)=C(O)C1=O |t:23| |
|---|
| Structure | 
|
|---|
Search and Browse
