| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Ligand | BDBM50518221 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1870946 (CHEMBL4372113) |
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| IC50 | 555±n/a nM |
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| Citation |  Pobsuk, N; Paracha, TU; Chaichamnong, N; Salaloy, N; Suphakun, P; Hannongbua, S; Choowongkomon, K; Pekthong, D; Chootip, K; Ingkaninan, K; Gleeson, MP Design, synthesis and evaluation of N Bioorg Med Chem Lett29:267-270 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Name: | cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Synonyms: | PDE5A_RAT | Pde5 | Pde5a | Phosphodiesterase 5A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 94547.60 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_155367 |
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| Residue: | 833 |
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| Sequence: | MLPFGDKTRDMVNAWFSERVHNIPVCKEGIRAHTESCSCSLPQSPHADNTTPGAPARKIS
ASEFDRPLRPIVVKDSEGTVSFLSDSGKKEQMPLTSPRFDSDEGDQCSRLLELVKDISSH
LDVTALCHKIFLHIHGLISADRYSLFLVCEDSSKDKFLVSRLFDVAEGSTLEEASNNCIR
LEWNKGIVGHVAAFGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA
QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFE
EQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCPDSFSRVFQMEWEEVGKSSEPLTREH
DANKINYMYAQYVKNTMEPLNIPDVTKDNRFPWTNENMGHINTHCIRSLLCTPIKNGKKN
KVIGVCQLVNKMEEKTGKIKAFNQNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVT
LEVLSYHASAAEEETRELQALAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDL
NLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLE
TLALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSTMEHHHFDQCLMVLNSPGNQILS
GLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNEFSFEDPLQKELFLAMLMTA
CDLSAITKPWPIQQRIAELVAAEFFDQGDRERKELNMEPADLMNREKKNKIPSMQVGFID
AICLQLYEALTHVSEDCLPLLDGCRKNRQKWQALADQQEKTLLNGESGQAKRD
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| BDBM50518221 |
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| n/a |
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| Name | BDBM50518221 |
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| Synonyms: | CHEMBL4450878 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N5O4S2 |
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| Mol. Mass. | 471.553 |
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| SMILES | COc1cc2nc(Nc3cccc(c3)S(N)(=O)=O)nc(NCc3cccs3)c2cc1OC |
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| Structure | 
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