| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cGMP-specific 3',5'-cyclic phosphodiesterase |
|---|
| Ligand | BDBM50518223 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1870946 (CHEMBL4372113) |
|---|
| IC50 | 116±n/a nM |
|---|
| Citation |  Pobsuk, N; Paracha, TU; Chaichamnong, N; Salaloy, N; Suphakun, P; Hannongbua, S; Choowongkomon, K; Pekthong, D; Chootip, K; Ingkaninan, K; Gleeson, MP Design, synthesis and evaluation of N Bioorg Med Chem Lett29:267-270 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cGMP-specific 3',5'-cyclic phosphodiesterase |
|---|
| Name: | cGMP-specific 3',5'-cyclic phosphodiesterase |
|---|
| Synonyms: | PDE5A_RAT | Pde5 | Pde5a | Phosphodiesterase 5A |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 94547.60 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_155367 |
|---|
| Residue: | 833 |
|---|
| Sequence: | MLPFGDKTRDMVNAWFSERVHNIPVCKEGIRAHTESCSCSLPQSPHADNTTPGAPARKIS
ASEFDRPLRPIVVKDSEGTVSFLSDSGKKEQMPLTSPRFDSDEGDQCSRLLELVKDISSH
LDVTALCHKIFLHIHGLISADRYSLFLVCEDSSKDKFLVSRLFDVAEGSTLEEASNNCIR
LEWNKGIVGHVAAFGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA
QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFE
EQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCPDSFSRVFQMEWEEVGKSSEPLTREH
DANKINYMYAQYVKNTMEPLNIPDVTKDNRFPWTNENMGHINTHCIRSLLCTPIKNGKKN
KVIGVCQLVNKMEEKTGKIKAFNQNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVT
LEVLSYHASAAEEETRELQALAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDL
NLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLE
TLALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSTMEHHHFDQCLMVLNSPGNQILS
GLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNEFSFEDPLQKELFLAMLMTA
CDLSAITKPWPIQQRIAELVAAEFFDQGDRERKELNMEPADLMNREKKNKIPSMQVGFID
AICLQLYEALTHVSEDCLPLLDGCRKNRQKWQALADQQEKTLLNGESGQAKRD
|
|
|
|---|
| BDBM50518223 |
|---|
| n/a |
|---|
| Name | BDBM50518223 |
|---|
| Synonyms: | CHEMBL4529354 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H17N5O3S |
|---|
| Mol. Mass. | 395.435 |
|---|
| SMILES | NS(=O)(=O)c1cccc(Nc2nc(NCc3ccco3)c3ccccc3n2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
