| Reaction Details |
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 | Report a problem with these data |
| Target | Maternal embryonic leucine zipper kinase |
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| Ligand | BDBM50518408 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1871191 (CHEMBL4372358) |
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| IC50 | 258±n/a nM |
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| Citation |  Kim, YY; Choi, J; Choi, K; Park, C; Kim, YH; Suh, KH; Ham, YJ; Jang, SY; Lee, KH; Hwang, KW Synthesis and evaluation of thieno[3,2-d]pyrimidine derivatives as novel FMS inhibitors. Bioorg Med Chem Lett29:271-275 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Maternal embryonic leucine zipper kinase |
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| Name: | Maternal embryonic leucine zipper kinase |
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| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) |
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| Type: | Enzyme |
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| Mol. Mass.: | 74665.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14680 |
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| Residue: | 651 |
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| Sequence: | MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
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| BDBM50518408 |
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| n/a |
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| Name | BDBM50518408 |
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| Synonyms: | CHEMBL4483816 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19N7OS |
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| Mol. Mass. | 429.498 |
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| SMILES | Cc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3csc4c(N)ncnc34)c12 |
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| Structure | 
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