| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM50072752 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_202316 |
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| Ki | 19±n/a nM |
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| Citation |  Perez, M; Pauwels, PJ; Pallard-Sigogneau, I; Fourrier, C; Chopin, P; Palmier, C; Colovray, V; Halazy, S Design and synthesis of new potent, silent 5-HT1A antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors. Bioorg Med Chem Lett8:3423-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A |
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| Type: | n/a |
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| Mol. Mass.: | 46122.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 422 |
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| Sequence: | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ
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| BDBM50072752 |
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| n/a |
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| Name | BDBM50072752 |
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| Synonyms: | 1-(1H-Indol-4-yloxy)-3-[3-phenyl-3-(4-trifluoromethyl-phenoxy)-propylamino]-propan-2-ol | CHEMBL115003 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27F3N2O3 |
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| Mol. Mass. | 484.5101 |
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| SMILES | OC(CNCCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1)COc1cccc2[nH]ccc12 |
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| Structure | 
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