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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 | ||
| Ligand | BDBM50519014 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1873795 (CHEMBL4375084) | ||
| Ki | 2400±n/a nM | ||
| Citation |  Szlávik, Z; Ondi, L; Csékei, M; Paczal, A; Szabó, ZB; Radics, G; Murray, J; Davidson, J; Chen, I; Davis, B; Hubbard, RE; Pedder, C; Dokurno, P; Surgenor, A; Smith, J; Robertson, A; LeToumelin-Braizat, G; Cauquil, N; Zarka, M; Demarles, D; Perron-Sierra, F; Claperon, A; Colland, F; Geneste, O; Kotschy, A Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity. J Med Chem62:6913-6924 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Induced myeloid leukemia cell differentiation protein Mcl-1 | |||
| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 | ||
| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT | ||
| Type: | Membrane; Single-pass membrane protein | ||
| Mol. Mass.: | 37332.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q07820 | ||
| Residue: | 350 | ||
| Sequence: |
| ||
| BDBM50519014 | |||
| n/a | |||
| Name | BDBM50519014 | ||
| Synonyms: | CHEMBL4458675 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H23N3O2S | ||
| Mol. Mass. | 417.523 | ||
| SMILES | CCc1sc2ncnc(N[C@H](Cc3ccccc3)C(O)=O)c2c1-c1ccccc1C |r,wU:10.10,(60.95,-30.92,;60.18,-29.58,;58.64,-29.58,;57.74,-30.83,;56.27,-30.36,;54.94,-31.14,;53.6,-30.37,;53.6,-28.82,;54.94,-28.05,;54.94,-26.51,;53.6,-25.74,;53.6,-24.2,;52.26,-23.44,;52.27,-21.89,;50.93,-21.13,;49.6,-21.9,;49.61,-23.45,;50.94,-24.21,;52.27,-26.52,;50.93,-25.75,;52.27,-28.06,;56.27,-28.81,;57.74,-28.34,;58.21,-26.87,;57.18,-25.74,;57.65,-24.28,;59.16,-23.95,;60.19,-25.09,;59.72,-26.56,;60.75,-27.7,)| | ||
| Structure | 
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