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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 | ||
| Ligand | BDBM50519051 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1873795 (CHEMBL4375084) | ||
| Ki | 810±n/a nM | ||
| Citation |  Szlávik, Z; Ondi, L; Csékei, M; Paczal, A; Szabó, ZB; Radics, G; Murray, J; Davidson, J; Chen, I; Davis, B; Hubbard, RE; Pedder, C; Dokurno, P; Surgenor, A; Smith, J; Robertson, A; LeToumelin-Braizat, G; Cauquil, N; Zarka, M; Demarles, D; Perron-Sierra, F; Claperon, A; Colland, F; Geneste, O; Kotschy, A Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity. J Med Chem62:6913-6924 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Induced myeloid leukemia cell differentiation protein Mcl-1 | |||
| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 | ||
| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT | ||
| Type: | Membrane; Single-pass membrane protein | ||
| Mol. Mass.: | 37332.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q07820 | ||
| Residue: | 350 | ||
| Sequence: |
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| BDBM50519051 | |||
| n/a | |||
| Name | BDBM50519051 | ||
| Synonyms: | CHEMBL4452148 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H21ClN2O3S | ||
| Mol. Mass. | 452.953 | ||
| SMILES | CCc1sc2ncnc(O[C@H](Cc3ccccc3)C(O)=O)c2c1-c1cccc(Cl)c1C |r,wU:10.10,(57.1,-14.15,;56.33,-12.81,;54.79,-12.81,;53.89,-14.06,;52.42,-13.59,;51.09,-14.36,;49.75,-13.59,;49.75,-12.05,;51.08,-11.28,;51.08,-9.74,;49.75,-8.97,;49.74,-7.43,;48.41,-6.66,;48.42,-5.12,;47.08,-4.36,;45.75,-5.13,;45.76,-6.68,;47.09,-7.44,;48.41,-9.74,;47.08,-8.98,;48.42,-11.28,;52.42,-12.04,;53.89,-11.57,;54.35,-10.1,;53.33,-8.97,;53.8,-7.51,;55.31,-7.18,;56.34,-8.32,;57.84,-7.99,;55.87,-9.78,;56.9,-10.93,)| | ||
| Structure | 
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