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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 | ||
| Ligand | BDBM50519058 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1873795 (CHEMBL4375084) | ||
| Ki | 890±n/a nM | ||
| Citation |  Szlávik, Z; Ondi, L; Csékei, M; Paczal, A; Szabó, ZB; Radics, G; Murray, J; Davidson, J; Chen, I; Davis, B; Hubbard, RE; Pedder, C; Dokurno, P; Surgenor, A; Smith, J; Robertson, A; LeToumelin-Braizat, G; Cauquil, N; Zarka, M; Demarles, D; Perron-Sierra, F; Claperon, A; Colland, F; Geneste, O; Kotschy, A Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity. J Med Chem62:6913-6924 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Induced myeloid leukemia cell differentiation protein Mcl-1 | |||
| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 | ||
| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT | ||
| Type: | Membrane; Single-pass membrane protein | ||
| Mol. Mass.: | 37332.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q07820 | ||
| Residue: | 350 | ||
| Sequence: |
| ||
| BDBM50519058 | |||
| n/a | |||
| Name | BDBM50519058 | ||
| Synonyms: | CHEMBL4473708 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H22N2O3S | ||
| Mol. Mass. | 418.508 | ||
| SMILES | CCc1sc2ncnc(O[C@H](Cc3ccccc3)C(O)=O)c2c1-c1ccccc1C |r,wU:10.10,(41.11,-47.36,;40.34,-46.02,;38.8,-46.03,;37.9,-47.27,;36.43,-46.8,;35.1,-47.58,;33.76,-46.81,;33.76,-45.26,;35.09,-44.49,;35.09,-42.95,;33.76,-42.18,;33.75,-40.64,;32.42,-39.88,;32.42,-38.33,;31.09,-37.57,;29.76,-38.34,;29.76,-39.89,;31.1,-40.65,;32.42,-42.96,;31.09,-42.19,;32.43,-44.5,;36.43,-45.25,;37.9,-44.78,;38.36,-43.31,;37.34,-42.18,;37.8,-40.72,;39.32,-40.39,;40.35,-41.53,;39.88,-43,;40.91,-44.14,)| | ||
| Structure | 
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