Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargettRNA (guanine-N(1)-)-methyltransferase
LigandBDBM50009672
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1874977 (CHEMBL4376266)
Kd 3300±n/a nM
Citation Zhong, W; Pasunooti, KK; Balamkundu, S; Wong, YH; Nah, Q; Gadi, V; Gnanakalai, S; Chionh, YH; McBee, ME; Gopal, P; Lim, SH; Olivier, N; Buurman, ET; Dick, T; Liu, CF; Lescar, J; Dedon, PC Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37- J Med Chem62:7788-7805 (2019) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
tRNA (guanine-N(1)-)-methyltransferase
Name:tRNA (guanine-N(1)-)-methyltransferase
Synonyms:2.1.1.228 | M1G-methyltransferase | TRMD_STAA8 | tRNA (guanine-N(1)-)-methyltransferase | tRNA [GM37] methyltransferase | trmD
Type:PROTEIN
Mol. Mass.:28051.04
Organism:Staphylococcus aureus (strain NCTC 8325 / PS 47)
Description:ChEMBL_119651
Residue:245
Sequence:
MKIDYLTLFPEMFDGVLNHSIMKRAQENNKLQINTVNFRDYAINKHNQVDDYPYGGGQGM
VLKPEPVFNAMEDLDVTEQTRVILMCPQGEPFSHQKAVELSKADHIVFICGHYEGYDERI
RTHLVTDEISMGDYVLTGGELPAMTMTDAIVRLIPGVLGNEQSHQDDSFSDGLLEFPQYT
RPREFKGLTVPDVLLSGNHANIDAWRHEQKLIRTYNKRPDLIEKYPLTNADKQILERYKI
GLKKG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50009672
n/a
NameBDBM50009672
Synonyms:AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocysteine | S-(5'-deoxyadenosin-5'-yl)-L-homocysteine | S-[1-(adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl]-L-homocysteine | S-adenosyl-L-homocysteine | SAH | US8895245, S-Adenosyl-L-homocysteine (SAH) | US9175331, 1 | US9333217, S-Adenosyl-L-homocysteine (SAH)
TypeSmall organic molecule
Emp. Form.C14H20N6O5S
Mol. Mass.384.411
SMILESN[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: