| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50293086 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1875745 (CHEMBL4377139) |
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| Ki | 0.900000±n/a nM |
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| Citation |  Cheviet, T; Lefebvre-Tournier, I; Wein, S; Peyrottes, S Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues. J Med Chem62:8365-8391 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Purine Nucleoside Phosphorylase (PNP) | pfPNP |
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| Type: | Enzyme |
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| Mol. Mass.: | 26857.85 |
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| Organism: | Plasmodium falciparum |
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| Description: | n/a |
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| Residue: | 245 |
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| Sequence: | MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFL
CVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHL
LIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAV
VEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKL
ATKYA
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| BDBM50293086 |
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| n/a |
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| Name | BDBM50293086 |
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| Synonyms: | (1S)-1,4-dideoxy-1,4-imino-1-(9-deazaguanin-9-yl)-D-ribitol | 1,4-DIDEOXY-1,4-IMINO-1-(S)-(9-DEAZAGUANIN-9-YL)-D-RIBITOL | 2-amino-7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL473922 | immucillin G |
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| Type | Small organic molecule |
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| Emp. Form. | C11H15N5O4 |
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| Mol. Mass. | 281.2679 |
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| SMILES | Nc1nc2c(c[nH]c2c(=O)[nH]1)[C@@H]1N[C@H](CO)[C@@H](O)[C@H]1O |r| |
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| Structure | 
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