| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50247149 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1875748 (CHEMBL4377142) |
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| Ki | 2.7±n/a nM |
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| Citation |  Cheviet, T; Lefebvre-Tournier, I; Wein, S; Peyrottes, S Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues. J Med Chem62:8365-8391 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Purine Nucleoside Phosphorylase (PNP) | pfPNP |
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| Type: | Enzyme |
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| Mol. Mass.: | 26857.85 |
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| Organism: | Plasmodium falciparum |
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| Description: | n/a |
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| Residue: | 245 |
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| Sequence: | MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFL
CVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHL
LIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAV
VEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKL
ATKYA
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| BDBM50247149 |
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| n/a |
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| Name | BDBM50247149 |
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| Synonyms: | 5'-Methylthio-ImmH | CHEMBL473929 | US9290501, (A) |
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| Type | Small organic molecule |
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| Emp. Form. | C12H16N4O3S |
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| Mol. Mass. | 296.345 |
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| SMILES | CSC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c1nc[nH]c2=O |r| |
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| Structure | 
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