| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
|---|
| Ligand | BDBM50059032 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_156007 |
|---|
| IC50 | 14±n/a nM |
|---|
| Citation |  Ho, GD; Silverman, L; Bercovici, A; Puchalski, C; Tulshian, D; Xia, Y; Czarniecki, M; Green, M; Cleven, R; Zhang, H; Fawzi, A Synthesis and evaluation of potent and selective c-GMP phosphodiesterase inhibitors. Bioorg Med Chem Lett9:7-12 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
|---|
| Name: | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
|---|
| Synonyms: | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | Heart phosphodiesterase | PDE1A | PDE1A_BOVIN | Phosphodiesterase 1 | Phosphodiesterase 1A |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 60835.05 |
|---|
| Organism: | BOVINE |
|---|
| Description: | Phosphodiesterase 1 0 BOVINE::P14100 |
|---|
| Residue: | 530 |
|---|
| Sequence: | MGSTATETEELENTTFKYLIGEQTEKMWQRLKGILRCLVKQLEKGDVNVIDLKKNIEYAA
SVLEAVYIDETRRLLDTDDELSDIQSDSVPSEVRDWLASTFTRKMGMMKKKSEEKPRFRS
IVHVVQAGIFVERMYRKSYHMVGLAYPEAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI
YELFTRYDLINRFKIPVSCLIAFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI
MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM
QEEEMNVLINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGLDKAKTMSL
ILHAADISHPAKSWKLHHRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF
IDFIVEPTFSLLTDSTEKIIIPLIEEDSKTKTPSYGASRRSNMKGTTNDGTYSPDYSLAS
VDLKSFKNSLVDIIQQNKERWKELAAQGEPDPHKNSDLVNAEEKHAETHS
|
|
|
|---|
| BDBM50059032 |
|---|
| n/a |
|---|
| Name | BDBM50059032 |
|---|
| Synonyms: | (6aR,9aS)-2-(3-methylbutyl)-5,6a,7,8,9,9a-hexahydro-5-methylcyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one | 2-isopentyl-5-methyl-(6aR,9aS)-3,4,5,8-tetrahydrocyclopenta[4,5]imidazo[2,1-b]purin-4-one | CHEMBL18744 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H23N5O |
|---|
| Mol. Mass. | 301.3867 |
|---|
| SMILES | CC(C)CCc1nc2N3[C@H]4CCC[C@H]4N=C3N(C)C(=O)c2[nH]1 |c:15| |
|---|
| Structure | 
|
|---|
Search and Browse
