| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 3 |
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| Ligand | BDBM50428286 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1877354 (CHEMBL4378748) |
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| IC50 | 2.0±n/a nM |
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| Citation |  Zhuang, C; Chen, F Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives. J Med Chem63:1490-1510 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 3 |
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| Name: | Receptor-interacting serine/threonine-protein kinase 3 |
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| Synonyms: | RIP-3 | RIP-like protein kinase 3 | RIP3 | RIPK3 | RIPK3_HUMAN | Receptor-interacting protein 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56886.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_881455 |
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| Residue: | 518 |
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| Sequence: | MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE
VKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL
LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG
GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP
SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVST
VKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSS
VPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG
PRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLA
PSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
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| BDBM50428286 |
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| n/a |
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| Name | BDBM50428286 |
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| Synonyms: | DABRAFENIB | GSK2118436A |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20F3N5O2S2 |
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| Mol. Mass. | 519.562 |
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| SMILES | CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F |
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| Structure | 
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