| Reaction Details |
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 | Report a problem with these data |
| Target | Dual serine/threonine and tyrosine protein kinase |
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| Ligand | BDBM50428286 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1877356 (CHEMBL4378750) |
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| IC50 | 29350±n/a nM |
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| Citation |  Zhuang, C; Chen, F Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives. J Med Chem63:1490-1510 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual serine/threonine and tyrosine protein kinase |
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| Name: | Dual serine/threonine and tyrosine protein kinase |
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| Synonyms: | DSTYK | DUSTY_HUMAN | Dusty PK | Dusty protein kinase | KIAA0472 | RIP-homologous kinase | RIP5 | RIPK5 | Receptor-interacting serine/threonine-protein kinase 5 | SGK496 | Sugen kinase 496 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 105208.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774238 |
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| Residue: | 929 |
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| Sequence: | MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHN
HTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQD
CNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAH
QGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDL
VNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESER
SPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAK
ALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMI
VETLNTMKEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKL
ISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRM
LWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAF
AASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGR
GQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDY
NYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKL
KNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWY
ICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLG
IVQPMLQGIMNRLCKSNSEQPNRGLDDST
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| BDBM50428286 |
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| n/a |
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| Name | BDBM50428286 |
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| Synonyms: | DABRAFENIB | GSK2118436A |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20F3N5O2S2 |
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| Mol. Mass. | 519.562 |
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| SMILES | CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F |
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| Structure | 
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