| Reaction Details |
|---|
 | Report a problem with these data |
| Target | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial |
|---|
| Ligand | BDBM50519662 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1877895 (CHEMBL4379289) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Zhao, L; Li, Y; Wang, Y; Qiao, Z; Miao, Z; Yang, J; Huang, L; Tian, C; Li, L; Chen, D; Yang, S Discovery of 4 J Med Chem62:10691-10710 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial |
|---|
| Name: | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial |
|---|
| Synonyms: | PDHK4 | PDK4 | PDK4_HUMAN | Pyruvate dehydrogenase kinase | Pyruvate dehydrogenase kinase 4 (PDK4) | Pyruvate dehydrogenase kinase isoform 4 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 46469.71 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16654 |
|---|
| Residue: | 411 |
|---|
| Sequence: | MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQE
LPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTL
IKVRNRHHNVVPTMAQGIIEYKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIF
SDSQTGNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQPIH
IVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIVVLGKEDLTIKISDRGGGVPL
RIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDA
IIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM
|
|
|
|---|
| BDBM50519662 |
|---|
| n/a |
|---|
| Name | BDBM50519662 |
|---|
| Synonyms: | CHEMBL4438748 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H23N3O5 |
|---|
| Mol. Mass. | 457.4779 |
|---|
| SMILES | CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)COc2ccc3c(c2)occc3=O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
