| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-adrenergic receptor kinase 2 |
|---|
| Ligand | BDBM50519662 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1877948 (CHEMBL4379342) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Zhao, L; Li, Y; Wang, Y; Qiao, Z; Miao, Z; Yang, J; Huang, L; Tian, C; Li, L; Chen, D; Yang, S Discovery of 4 J Med Chem62:10691-10710 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-adrenergic receptor kinase 2 |
|---|
| Name: | Beta-adrenergic receptor kinase 2 |
|---|
| Synonyms: | ADRBK2 | ARBK2_HUMAN | BARK2 | GRK3 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 79721.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_615172 |
|---|
| Residue: | 688 |
|---|
| Sequence: | MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN
QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC
SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE
IILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPE
VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE
LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA
DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARK
RAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNL
LTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRR
APKFLNKPRSGTVELPKPSLCHRNSNGL
|
|
|
|---|
| BDBM50519662 |
|---|
| n/a |
|---|
| Name | BDBM50519662 |
|---|
| Synonyms: | CHEMBL4438748 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H23N3O5 |
|---|
| Mol. Mass. | 457.4779 |
|---|
| SMILES | CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)COc2ccc3c(c2)occc3=O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
