| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Adenosine receptor A1 |
|---|
| Ligand | BDBM50519748 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1878366 (CHEMBL4379760) |
|---|
| Ki | 10400±n/a nM |
|---|
| Citation |  Matos, MJ; Vilar, S; Vazquez-Rodriguez, S; Kachler, S; Klotz, KN; Buccioni, M; Delogu, G; Santana, L; Uriarte, E; Borges, F Structure-Based Optimization of Coumarin hA J Med Chem63:2577-2587 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Adenosine receptor A1 |
|---|
| Name: | Adenosine receptor A1 |
|---|
| Synonyms: | A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT) |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 36520.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P30542 |
|---|
| Residue: | 326 |
|---|
| Sequence: | MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
|
|
|
|---|
| BDBM50519748 |
|---|
| n/a |
|---|
| Name | BDBM50519748 |
|---|
| Synonyms: | CHEMBL4471897 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H14O4 |
|---|
| Mol. Mass. | 294.3014 |
|---|
| SMILES | CC(=O)COc1cccc2cc(-c3ccccc3)c(=O)oc12 |
|---|
| Structure | 
|
|---|
Search and Browse
