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TargetCannabinoid receptor 1
LigandBDBM50519776
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1878393 (CHEMBL4379787)
Ki 88±n/a nM
Citation Garai, SKulkarni, PMSchaffer, PCLeo, LMBrandt, ALZagzoog, ABlack, TLin, XHurst, DPJanero, DRAbood, MEZimmowitch, AStraiker, APertwee, RGKelly, MSzczesniak, AMDenovan-Wright, EMMackie, KHohmann, AGReggio, PHLaprairie, RBThakur, GA Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators. J Med Chem63:542-568 (2020) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52868.96
Organism:Homo sapiens (Human)
Description:P21554
Residue:472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50519776
n/a
NameBDBM50519776
Synonyms:CHEMBL4467516
TypeSmall organic molecule
Emp. Form.C22H15F3N2O2
Mol. Mass.396.3619
SMILES[O-][N+](=O)CC(c1c([nH]c2cc(F)ccc12)-c1cccc(F)c1)c1ccccc1F
Structure
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