Reaction Details |
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Target | Aldo-keto reductase family 1 member B10 |
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Ligand | BDBM50519874 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1878641 (CHEMBL4380035) |
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IC50 | 56240±n/a nM |
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Citation | Hlavá?, M; Ková?iková, L; Prnová, M?; ?ramel, P; Addová, G; Májeková, M; Hanquet, G; Bohá?, A; ?tefek, M Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity. J Med Chem63:369-381 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aldo-keto reductase family 1 member B10 |
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Name: | Aldo-keto reductase family 1 member B10 |
Synonyms: | AK1BA_HUMAN | AKR1B10 | AKR1B11 | ARL-1 | ARP | Aldo-keto reductase family 1 member B10 | Aldo-keto reductase family 1 member B10 (AKR1B10) | Aldo-keto reductase family member 1B10 (AKR1B10) | Aldose reductase-like | Aldose reductase-related protein | SI reductase | Small intestine reductase | hARP |
Type: | Protein |
Mol. Mass.: | 36024.67 |
Organism: | Homo sapiens (Human) |
Description: | O60218. 1ZUA; 4JII; 4GQ0 |
Residue: | 316 |
Sequence: | MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQ
EKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD
DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP
VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK
HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACN
VLQSSHLEDYPFNAEY
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BDBM50519874 |
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n/a |
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Name | BDBM50519874 |
Synonyms: | CHEMBL4582264 |
Type | Small organic molecule |
Emp. Form. | C11H8N4O3 |
Mol. Mass. | 244.2062 |
SMILES | OC(=O)Cn1c2ccccc2c2n[nH]c(=O)nc12 |
Structure |
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