Reaction Details |
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Target | Aldo-keto reductase family 1 member B1 |
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Ligand | BDBM50080464 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1878644 (CHEMBL4380038) |
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IC50 | 1157±n/a nM |
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Citation | Hlavá?, M; Ková?iková, L; Prnová, M?; ?ramel, P; Addová, G; Májeková, M; Hanquet, G; Bohá?, A; ?tefek, M Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity. J Med Chem63:369-381 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aldo-keto reductase family 1 member B1 |
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Name: | Aldo-keto reductase family 1 member B1 |
Synonyms: | ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1 |
Type: | PROTEIN |
Mol. Mass.: | 35797.87 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1512484 |
Residue: | 316 |
Sequence: | MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
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BDBM50080464 |
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n/a |
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Name | BDBM50080464 |
Synonyms: | ALR2 inhibitor, 12 | CHEMBL1405739 |
Type | Small organic molecule |
Emp. Form. | C11H8N4O2S |
Mol. Mass. | 260.272 |
SMILES | OC(=O)Cn1c2ccccc2c2nnc(S)nc12 |
Structure |
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