| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 |
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| Ligand | BDBM50080464 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1878635 (CHEMBL4380029) |
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| IC50 | 116±n/a nM |
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| Citation |  Hlavá?, M; Ková?iková, L; Prnová, M?; ?ramel, P; Addová, G; Májeková, M; Hanquet, G; Bohá?, A; ?tefek, M Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity. J Med Chem63:369-381 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B1 |
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| Name: | Aldo-keto reductase family 1 member B1 |
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| Synonyms: | ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35797.87 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1512484 |
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| Residue: | 316 |
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| Sequence: | MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
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| BDBM50080464 |
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| n/a |
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| Name | BDBM50080464 |
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| Synonyms: | ALR2 inhibitor, 12 | CHEMBL1405739 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H8N4O2S |
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| Mol. Mass. | 260.272 |
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| SMILES | OC(=O)Cn1c2ccccc2c2nnc(S)nc12 |
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| Structure | 
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