Reaction Details |
| Report a problem with these data |
Target | Sodium-dependent dopamine transporter |
---|
Ligand | BDBM50520001 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1878790 (CHEMBL4380184) |
---|
IC50 | 1090±n/a nM |
---|
Citation | Kalaba, P; Ili?, M; Aher, NY; Draga?evi?, V; Wieder, M; Zehl, M; Wackerlig, J; Beyl, S; Sartori, SB; Ebner, K; Roller, A; Lukic, N; Beryozkina, T; Gonzalez, ERP; Neill, P; Khan, JA; Bakulev, V; Leban, JJ; Hering, S; Pifl, C; Singewald, N; Lubec, J; Urban, E; Sitte, HH; Langer, T; Lubec, G Structure-Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters. J Med Chem63:391-417 (2020) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Sodium-dependent dopamine transporter |
---|
Name: | Sodium-dependent dopamine transporter |
Synonyms: | DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 68497.11 |
Organism: | Homo sapiens (Human) |
Description: | Q01959 |
Residue: | 620 |
Sequence: | MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
|
|
|
BDBM50520001 |
---|
n/a |
---|
Name | BDBM50520001 |
Synonyms: | CHEMBL4473574 |
Type | Small organic molecule |
Emp. Form. | C17H14BrNOS2 |
Mol. Mass. | 392.333 |
SMILES | [O-][S@+](Cc1cscn1)[C@H](c1ccccc1)c1ccc(Br)cc1 |r| |
Structure |
|