| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tubulin beta chain |
|---|
| Ligand | BDBM50520178 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1879190 (CHEMBL4380584) |
|---|
| Kd | 2660±n/a nM |
|---|
| Citation |  Chen, H; Deng, S; Wang, Y; Albadari, N; Kumar, G; Ma, D; Li, W; White, SW; Miller, DD; Li, W Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties. J Med Chem63:827-846 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tubulin beta chain |
|---|
| Name: | Tubulin beta chain |
|---|
| Synonyms: | Beta-tubulin | TBB_PIG | Tubulin beta chain |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 49840.26 |
|---|
| Organism: | Sus scrofa |
|---|
| Description: | ChEMBL_105107 |
|---|
| Residue: | 445 |
|---|
| Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEGEEDEA
|
|
|
|---|
| BDBM50520178 |
|---|
| n/a |
|---|
| Name | BDBM50520178 |
|---|
| Synonyms: | CHEMBL4468642 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H21NO5 |
|---|
| Mol. Mass. | 379.4058 |
|---|
| SMILES | COc1cc(cc(OC)c1OC)C(=O)c1cccc(n1)-c1ccc(C)c(O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
