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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50074464 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_51114 (CHEMBL664960) | ||
| Ki | 6.7±n/a nM | ||
| Citation |  Chorvat, RJ; Bakthavatchalam, R; Beck, JP; Gilligan, PJ; Wilde, RG; Cocuzza, AJ; Hobbs, FW; Cheeseman, RS; Curry, M; Rescinito, JP; Krenitsky, P; Chidester, D; Yarem, JA; Klaczkiewicz, JD; Hodge, CN; Aldrich, PE; Wasserman, ZR; Fernandez, CH; Zaczek, R; Fitzgerald, LW; Huang, SM; Shen, HL; Wong, YN; Chien, BM; Arvanitis, A Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines. J Med Chem42:833-48 (1999) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50074464 | |||
| n/a | |||
| Name | BDBM50074464 | ||
| Synonyms: | CHEMBL168476 | [9-(2-Bromo-4-isopropyl-phenyl)-2,8-dimethyl-9H-purin-6-yl]-bis-(2-methoxy-ethyl)-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H30BrN5O2 | ||
| Mol. Mass. | 476.41 | ||
| SMILES | COCCN(CCOC)c1nc(C)nc2n(c(C)nc12)-c1ccc(cc1Br)C(C)C |(13.93,1.76,;13.93,.21,;12.61,-.56,;12.61,-2.1,;11.28,-2.86,;9.94,-2.1,;8.62,-2.86,;7.29,-2.1,;5.95,-2.86,;11.28,-4.4,;9.94,-5.16,;9.94,-6.69,;8.61,-7.48,;11.28,-7.46,;12.61,-6.69,;14.05,-7.16,;14.96,-5.93,;16.49,-5.94,;14.05,-4.69,;12.61,-5.16,;14.68,-8.57,;13.77,-9.8,;14.4,-11.21,;15.93,-11.38,;16.84,-10.13,;16.21,-8.73,;17.12,-7.48,;16.55,-12.79,;18.07,-12.96,;15.63,-14.03,)| | ||
| Structure | 
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