| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 2 |
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| Ligand | BDBM50520653 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1881471 (CHEMBL4382970) |
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| Ki | 1.7±n/a nM |
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| Citation |  Qin, C; Hu, Y; Zhou, B; Fernandez-Salas, E; Yang, CY; Liu, L; McEachern, D; Przybranowski, S; Wang, M; Stuckey, J; Meagher, J; Bai, L; Chen, Z; Lin, M; Yang, J; Ziazadeh, DN; Xu, F; Hu, J; Xiang, W; Huang, L; Li, S; Wen, B; Sun, D; Wang, S Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem61:6685-6704 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 2 |
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| Name: | Bromodomain-containing protein 2 |
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| Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 2 | Bromodomain-containing protein 2 (BRD2) | KIAA9001 | RING3 |
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| Type: | Protein |
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| Mol. Mass.: | 88085.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25440 |
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| Residue: | 801 |
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| Sequence: | MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
SDSSSSSSSSSSSDTSDSDSG
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| BDBM50520653 |
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| n/a |
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| Name | BDBM50520653 |
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| Synonyms: | CHEMBL4555209 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19N5OS |
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| Mol. Mass. | 401.484 |
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| SMILES | Cc1nnc2COCc3c(Cc4ccccc4)c(sc3-n12)C#Cc1cnn(C)c1 |
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| Structure | 
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