| Reaction Details |
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 | Report a problem with these data |
| Target | Myc proto-oncogene protein/Protein max |
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| Ligand | BDBM50520739 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1882034 (CHEMBL4383533) |
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| IC50 | 28900±n/a nM |
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| Citation |  Carabet, LA; Lallous, N; Leblanc, E; Ban, F; Morin, H; Lawn, S; Ghaidi, F; Lee, J; Mills, IG; Gleave, ME; Rennie, PS; Cherkasov, A Computer-aided drug discovery of Myc-Max inhibitors as potential therapeutics for prostate cancer. Eur J Med Chem160:108-119 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Myc proto-oncogene protein/Protein max |
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| Name: | Myc proto-oncogene protein/Protein max |
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| Synonyms: | c-Myc/Max |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1882034 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Myc proto-oncogene protein |
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| Synonyms: | BHLHE39 | Class E basic helix-loop-helix protein 39 | MYC | MYC_HUMAN | Proto-oncogene c-Myc | Transcription factor p64 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48794.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_935266 |
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| Residue: | 439 |
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| Sequence: | MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPP
LSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD
DETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQD
LSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVL
HEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRC
HVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHN
VLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLL
RKRREQLKHKLEQLRNSCA
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| Component 2 |
| Name: | Protein max |
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| Synonyms: | BHLHD4 | Class D basic helix-loop-helix protein 4 | MAX | MAX_HUMAN | Myc-associated factor X |
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| Type: | PROTEIN |
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| Mol. Mass.: | 18273.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_935265 |
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| Residue: | 160 |
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| Sequence: | MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASR
AQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDN
SLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS
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| BDBM50520739 |
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| n/a |
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| Name | BDBM50520739 |
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| Synonyms: | CHEMBL443375 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H11NOS2 |
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| Mol. Mass. | 249.352 |
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| SMILES | CCc1ccc(\C=C2/SC(=S)NC2=O)cc1 |
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| Structure | 
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