Reaction Details |
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Target | Thromboxane A2 receptor |
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Ligand | BDBM50075628 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_209591 (CHEMBL814726) |
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IC50 | 300±n/a nM |
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Citation | Soyka, R; Guth, BD; Weisenberger, HM; Luger, P; Müller, TH Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors. J Med Chem42:1235-49 (1999) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thromboxane A2 receptor |
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Name: | Thromboxane A2 receptor |
Synonyms: | Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta |
Type: | Enyzme |
Mol. Mass.: | 37445.28 |
Organism: | Homo sapiens (Human) |
Description: | P21731 |
Residue: | 343 |
Sequence: | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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BDBM50075628 |
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n/a |
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Name | BDBM50075628 |
Synonyms: | (E)-6-{3-[N'-Isobutyl-N''-(1H-tetrazol-5-yl)-guanidino]-phenyl}-6-pyridin-3-yl-hex-5-enoic acid | CHEMBL421854 |
Type | Small organic molecule |
Emp. Form. | C23H28N8O2 |
Mol. Mass. | 448.5208 |
SMILES | CC(C)CNC(Nc1cccc(c1)C(=CCCCC(O)=O)c1cccnc1)=Nc1nnn[nH]1 |w:27.29,14.15| |
Structure |
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