| Reaction Details |
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 | Report a problem with these data |
| Target | Adenylate cyclase type 8 |
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| Ligand | BDBM50521057 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1883019 (CHEMBL4384518) |
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| IC50 | 7900±n/a nM |
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| Citation |  Kaur, J; Soto-Velasquez, M; Ding, Z; Ghanbarpour, A; Lill, MA; van Rijn, RM; Watts, VJ; Flaherty, DP Optimization of a 1,3,4-oxadiazole series for inhibition of Ca Eur J Med Chem162:568-585 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenylate cyclase type 8 |
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| Name: | Adenylate cyclase type 8 |
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| Synonyms: | 4.6.1.1 | AC8 | ADCY8 | ADCY8_HUMAN | ATP pyrophosphate-lyase 8 | Adenylate cyclase type 8 | Adenylate cyclase type VIII | Adenylyl cyclase 8 | Ca(2+)/calmodulin-activated adenylyl cyclase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 140131.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104878 |
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| Residue: | 1251 |
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| Sequence: | MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGS
GSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASG
SGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRK
SEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHT
YLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTS
LLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEAR
LRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADV
KGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAH
CCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKL
ESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPED
IVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHV
QSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAF
IVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINE
TYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTG
VLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEV
SLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVA
RHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDE
LLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKH
SFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLIL
KDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLV
QSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP
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| BDBM50521057 |
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| n/a |
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| Name | BDBM50521057 |
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| Synonyms: | CHEMBL4467466 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16F3N3O2 |
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| Mol. Mass. | 387.3551 |
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| SMILES | FC(F)(F)c1cccc(c1)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 |
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| Structure | 
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