| Reaction Details |
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 | Report a problem with these data |
| Target | Presenilin-1 |
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| Ligand | BDBM50521238 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1883816 (CHEMBL4385315) |
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| EC50 | 0.006400±n/a nM |
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| Citation |  Blass, BE Bridged Piperidine Derivatives Useful as ?-Secretase Inhibitors for the Treatment of Alzheimer's Disease. ACS Med Chem Lett10:6-7 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Presenilin-1 |
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| Name: | Presenilin-1 |
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| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
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| Type: | n/a |
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| Mol. Mass.: | 52657.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49768 |
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| Residue: | 467 |
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| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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| BDBM50521238 |
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| n/a |
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| Name | BDBM50521238 |
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| Synonyms: | CHEMBL4589937 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H29F2N7O |
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| Mol. Mass. | 469.5302 |
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| SMILES | [H][C@]12CC[C@]([H])(CN(C1)c1ccnc(OC)c1)[C@H]2Nc1nc(N(CC)c2cc(F)cc(F)c2)n(C)n1 |r,TLB:18:17:3.2:6.8.7,THB:9:7:3.2:17| |
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| Structure | 
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