| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene synthase |
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| Ligand | BDBM50059852 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_70138 |
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| IC50 | 21±n/a nM |
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| Citation |  Liu, R; Dong, DL; Sherlock, R; Nestler, HP; Gennari, C; Mielgo, A; Scolastico, C Novel reverse-turn mimics inhibit farnesyl transferase. Bioorg Med Chem Lett9:847-52 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene synthase |
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| Name: | Squalene synthase |
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| Synonyms: | Squalene synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48292.44 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_70138 |
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| Residue: | 417 |
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| Sequence: | MEFVKCLGHPEEFYNLLRFQMGGRRKVIPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQA
LDGEMRHAVCIFYLVLRALDTLEDDMTISIERKVPLLHNFHSYLYEPDWRFTESKEKDRQ
VLEDFPTISLEFRNLAEKYQTVIVDVCQKMGFGMAEFLDKRVTSEREWDKYCHYVAGLVG
IGLSRLFSASELEDPLIGEDTERANSMGLFLQKTNIIRDYLEDQREGREFWPQETWSKYV
KKLGDFAKPENIDLAVQCLNELITNTLHHIPDVITYLSRLRNQSIFNFCAIPQVMAIATL
AACYNNQQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIHQYMEEIYHRIPNSDPCSTKTQ
QIISTIRTQNLPNCQLVSRSHYSPIYLSFVMLLAALSWQYLSTLSQVTEDYVQTGEH
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| BDBM50059852 |
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| n/a |
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| Name | BDBM50059852 |
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| Synonyms: | (S)-2-((S)-2-((S)-2-((R)-2-amino-3-mercaptopropylamino)-3-methylbutylamino)-3-phenylpropanamido)-4-(methylthio)butanoic acid | (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-butylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid | CHEMBL91722 | N-[2(S)-[2(R)-amino-3-mercaptopropylamino]-3-methylbutyl]-Phe-Met-OH |
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| Type | Small organic molecule |
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| Emp. Form. | C22H38N4O3S2 |
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| Mol. Mass. | 470.692 |
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| SMILES | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC[C@@H](NC[C@@H](N)CS)C(C)C)C(O)=O |
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| Structure | 
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