Reaction Details |
| Report a problem with these data |
Target | Potassium voltage-gated channel subfamily KQT member 4 |
---|
Ligand | BDBM50521287 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1883887 (CHEMBL4385386) |
---|
EC50 | 890±n/a nM |
---|
Citation | Wang, L; Qiao, GH; Hu, HN; Gao, ZB; Nan, FJ Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity. ACS Med Chem Lett10:27-33 (2019) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Potassium voltage-gated channel subfamily KQT member 4 |
---|
Name: | Potassium voltage-gated channel subfamily KQT member 4 |
Synonyms: | KCNQ (Kv7) potassium channel | KCNQ4 | KCNQ4_HUMAN | KQT-like 4 | Potassium channel subunit alpha KvLQT4 | Potassium voltage-gated channel subfamily KQT member 4 | Voltage-gated potassium channel subunit Kv7.4 |
Type: | PROTEIN |
Mol. Mass.: | 77131.10 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1520985 |
Residue: | 695 |
Sequence: | MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPG
PGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLST
IQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFI
VFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELIT
AWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLA
AGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRA
YLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHR
PGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQ
KSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRIL
KFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKG
DKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLF
DPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
|
|
|
BDBM50521287 |
---|
n/a |
---|
Name | BDBM50521287 |
Synonyms: | CHEMBL4448132 |
Type | Small organic molecule |
Emp. Form. | C22H24FN3O4 |
Mol. Mass. | 413.4421 |
SMILES | CCOC(=O)Nc1ccc(cc1NC(=O)OCC)N(CC#C)Cc1ccc(F)cc1 |
Structure |
|