| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily KQT member 4 |
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| Ligand | BDBM50143558 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1883897 (CHEMBL4385396) |
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| EC50 | 5900±n/a nM |
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| Citation |  Wang, L; Qiao, GH; Hu, HN; Gao, ZB; Nan, FJ Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity. ACS Med Chem Lett10:27-33 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily KQT member 4 |
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| Name: | Potassium voltage-gated channel subfamily KQT member 4 |
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| Synonyms: | KCNQ (Kv7) potassium channel | KCNQ4 | KCNQ4_HUMAN | KQT-like 4 | Potassium channel subunit alpha KvLQT4 | Potassium voltage-gated channel subfamily KQT member 4 | Voltage-gated potassium channel subunit Kv7.4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 77131.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1520985 |
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| Residue: | 695 |
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| Sequence: | MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPG
PGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLST
IQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFI
VFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELIT
AWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLA
AGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRA
YLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHR
PGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQ
KSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRIL
KFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKG
DKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLF
DPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
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| BDBM50143558 |
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| n/a |
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| Name | BDBM50143558 |
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| Synonyms: | CHEMBL41355 | EZOGABINE | N-(2-amino-4-(4-fluorobenzylamino)-phenyl)carbamic acid ethylester | RETIGABINE | [2-Amino-4-(4-fluoro-benzylamino)-phenyl]-carbamic acid ethyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18FN3O2 |
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| Mol. Mass. | 303.3314 |
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| SMILES | CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N |
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| Structure | 
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