Reaction Details |
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Target | Prothrombin |
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Ligand | BDBM50076229 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_208313 (CHEMBL812832) |
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Ki | 2.4±n/a nM |
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Citation | St Charles, R; Matthews, JH; Zhang, E; Tulinsky, A Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin. J Med Chem42:1376-83 (1999) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prothrombin |
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Name: | Prothrombin |
Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
Type: | Protein |
Mol. Mass.: | 70029.57 |
Organism: | Homo sapiens (Human) |
Description: | P00734 |
Residue: | 622 |
Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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BDBM50076229 |
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n/a |
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Name | BDBM50076229 |
Synonyms: | (1S,7S)-7-Amino-7-benzyl-8-oxo-hexahydro-pyrazolo[1,2-a]pyridazine-1-carboxylic acid [(S)-4-guanidino-1-(thiazole-2-carbonyl)-butyl]-amide | (1S,7S)-7-amino-7-benzyl-N-((S)-5-guanidino-1-oxo-1-(thiazol-2-yl)pentan-2-yl)-8-oxo-hexahydro-1H-pyrazolo[1,2-a]pyridazine-1-carboxamide | CHEMBL32182 |
Type | Small organic molecule |
Emp. Form. | C24H32N8O3S |
Mol. Mass. | 512.628 |
SMILES | NC(=N)NCCC[C@H](NC(=O)[C@@H]1CCN2CC[C@@](N)(Cc3ccccc3)C(=O)N12)C(=O)c1nccs1 |
Structure |
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