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TargetStromelysin-1
LigandBDBM50076336
Substrate/Competitorn/a
Meas. Tech.ChEMBL_104736
Ki 420±n/a nM
Citation Jacobsen EJMitchell MAHendges SKBelonga KLSkaletzky LLStelzer LSLindberg TJFritzen ELSchostarez HJO'Sullivan TJMaggiora LLStuchly CWLaborde ALKubicek MFPoorman RABeck JMMiller HRPetzold GLScott PSTruesdell SEWallace TLWilks JWFisher CGoodman LVKaytes PS Synthesis of a series of stromelysin-selective thiadiazole urea matrix metalloproteinase inhibitors. J Med Chem 42:1525-36 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Stromelysin-1
Name:Matrix metalloproteinase (2 and 3)
Synonyms:MMP-3 | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | Stromelysin 1 | Transin-1
Type:Enzyme
Mol. Mass.:53973.13
Organism:Homo sapiens (Human)
Description:
Residue:477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50076336
n/a
NameBDBM50076336
Synonyms:1-[(S)-1-Benzyl-2-oxo-2-(4-pyrimidin-2-yl-piperazin-1-yl)-ethyl]-3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-urea | CHEMBL39580
TypeSmall organic molecule
Emp. Form.C20H22N8O2S2
Mol. Mass.470.571
SMILESSc1nnc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCN(CC2)c2ncccn2)s1
Structure
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