Reaction Details |
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Target | Stromelysin-1 |
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Ligand | BDBM50076366 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_104736 (CHEMBL710736) |
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Ki | 330±n/a nM |
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Citation | Jacobsen, EJ; Mitchell, MA; Hendges, SK; Belonga, KL; Skaletzky, LL; Stelzer, LS; Lindberg, TJ; Fritzen, EL; Schostarez, HJ; O'Sullivan, TJ; Maggiora, LL; Stuchly, CW; Laborde, AL; Kubicek, MF; Poorman, RA; Beck, JM; Miller, HR; Petzold, GL; Scott, PS; Truesdell, SE; Wallace, TL; Wilks, JW; Fisher, C; Goodman, LV; Kaytes, PS Synthesis of a series of stromelysin-selective thiadiazole urea matrix metalloproteinase inhibitors. J Med Chem42:1525-36 (1999) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Stromelysin-1 |
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Name: | Stromelysin-1 |
Synonyms: | MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1 |
Type: | Enzyme |
Mol. Mass.: | 53973.13 |
Organism: | Homo sapiens (Human) |
Description: | P08254 |
Residue: | 477 |
Sequence: | MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
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BDBM50076366 |
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n/a |
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Name | BDBM50076366 |
Synonyms: | (S)-N-Methyl-3-(4-nitro-phenyl)-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide | CHEMBL418063 |
Type | Small organic molecule |
Emp. Form. | C13H14N6O4S2 |
Mol. Mass. | 382.418 |
SMILES | CNC(=O)C(Cc1ccc(cc1)[N+]([O-])=O)NC(=O)Nc1n[n-]c(=[SH+])s1 |
Structure |
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