| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50076334 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_106319 (CHEMBL714731) |
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| Ki | 6200±n/a nM |
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| Citation |  Jacobsen, EJ; Mitchell, MA; Hendges, SK; Belonga, KL; Skaletzky, LL; Stelzer, LS; Lindberg, TJ; Fritzen, EL; Schostarez, HJ; O'Sullivan, TJ; Maggiora, LL; Stuchly, CW; Laborde, AL; Kubicek, MF; Poorman, RA; Beck, JM; Miller, HR; Petzold, GL; Scott, PS; Truesdell, SE; Wallace, TL; Wilks, JW; Fisher, C; Goodman, LV; Kaytes, PS Synthesis of a series of stromelysin-selective thiadiazole urea matrix metalloproteinase inhibitors. J Med Chem42:1525-36 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50076334 |
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| n/a |
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| Name | BDBM50076334 |
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| Synonyms: | (S)-N-(3,4-Dimethoxy-benzyl)-3-phenyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide | CHEMBL287974 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23N5O4S2 |
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| Mol. Mass. | 473.568 |
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| SMILES | COc1ccc(CNC(=O)[C@H](Cc2ccccc2)NC(=O)Nc2nnc(S)s2)cc1OC |
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| Structure | 
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