| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 |
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| Ligand | BDBM50521533 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1884566 (CHEMBL4386148) |
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| IC50 | 603±n/a nM |
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| Citation |  Jorda, R; Havlí?ek, L; ?turc, A; Tu?ková, D; Daumová, L; Alam, M; ?kerlová, J; Nekardová, M; Pe?ina, M; Pospí?il, T; ?iroká, J; Urbánek, L; Pachl, P; ?ezá?ová, P; Strnad, M; Klener, P; Kry?tof, V 3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models. J Med Chem62:4606-4623 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 |
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| Name: | Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 |
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| Synonyms: | CDK4/CycD | CDK4/CycD1 | CDK4/Cyclin D1 | CDK4/D1 | Cyclin-Dependent Kinase 4 (CDK4) | Cyclin-dependent kinase 4 | Cyclin-dependent kinase 4/G1/S-specific cyclin D1 | Cyclin-dependent kinase 4/cyclin D1 |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | CDK4/D1 complexes were purified from insect cells co-infected with baculovirus vectors containing each of the components. |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| Component 2 |
| Name: | G1/S-specific cyclin-D1 |
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| Synonyms: | B-cell lymphoma 1 protein | BCL-1 | BCL-1 oncogene | BCL1 | CCND1 | CCND1_HUMAN | PRAD1 | PRAD1 oncogene |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33717.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 295 |
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| Sequence: | MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK
HAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
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| BDBM50521533 |
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| n/a |
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| Name | BDBM50521533 |
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| Synonyms: | CHEMBL4540226 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25N7S |
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| Mol. Mass. | 419.546 |
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| SMILES | CC(C)c1n[nH]c2c(NCc3ccc(cc3)-c3ccccn3)nc(SCCN)nc12 |
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| Structure | 
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