Reaction Details |
| Report a problem with these data |
Target | Polyamine deacetylase HDAC10 |
---|
Ligand | BDBM50521588 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1884822 (CHEMBL4386404) |
---|
IC50 | 4.0±n/a nM |
---|
Citation | Géraldy, M; Morgen, M; Sehr, P; Steimbach, RR; Moi, D; Ridinger, J; Oehme, I; Witt, O; Malz, M; Nogueira, MS; Koch, O; Gunkel, N; Miller, AK Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated. J Med Chem62:4426-4443 (2019) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Polyamine deacetylase HDAC10 |
---|
Name: | Polyamine deacetylase HDAC10 |
Synonyms: | HD10 | HDA10_HUMAN | HDAC10 | Histone deacetylase | Histone deacetylase 10 | Human HDAC10 |
Type: | Chromatin regulator; hydrolase; repressor |
Mol. Mass.: | 71431.89 |
Organism: | Homo sapiens (Human) |
Description: | Q969S8 |
Residue: | 669 |
Sequence: | MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV
LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
LQCHPHLVA
|
|
|
BDBM50521588 |
---|
n/a |
---|
Name | BDBM50521588 |
Synonyms: | CHEMBL4578278 |
Type | Small organic molecule |
Emp. Form. | C21H23N3O2 |
Mol. Mass. | 349.4262 |
SMILES | ONC(=O)c1ccc(Cn2cc(CN3CCCC3)c3ccccc23)cc1 |
Structure |
|