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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50076623 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_50955 | ||
| Ki | 12±n/a nM | ||
| Citation |  Beck, JP; Arvanitis, AG; Curry, MA; Rescinito, JT; Fitzgerald, LW; Gilligan, PJ; Zaczek, R; Trainor, GL Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists. Bioorg Med Chem Lett9:967-72 (1999) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50076623 | |||
| n/a | |||
| Name | BDBM50076623 | ||
| Synonyms: | 9-(2-Bromo-4-isopropyl-phenyl)-6-[cyclopropylmethyl-(2-methoxy-ethyl)-amino]-2,7-dimethyl-7,9-dihydro-purin-8-one | CHEMBL172358 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H30BrN5O2 | ||
| Mol. Mass. | 488.421 | ||
| SMILES | COCCN(CC1CC1)c1nc(C)nc2n(-c3ccc(cc3Br)C(C)C)c(=O)n(C)c12 |(.52,2.98,;.52,1.44,;1.87,.67,;1.87,-.87,;3.22,-1.63,;4.56,-.86,;4.55,.68,;5.32,2.01,;3.78,2.01,;3.23,-3.17,;1.9,-3.94,;1.9,-5.49,;.56,-6.26,;3.23,-6.26,;4.56,-5.48,;6.04,-5.95,;6.52,-7.4,;5.49,-8.55,;5.98,-10.02,;7.49,-10.32,;8.52,-9.17,;8.03,-7.71,;9.04,-6.56,;7.98,-11.79,;9.48,-12.09,;6.95,-12.93,;6.94,-4.7,;8.48,-4.69,;6.03,-3.45,;6.49,-1.99,;4.56,-3.94,)| | ||
| Structure | 
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