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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50076777 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_50977 | ||
| Ki | 32±n/a nM | ||
| Citation |  Cocuzza, AJ; Chidester, DR; Culp, S; Fitzgerald, L; Gilligan, P Use of the Suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists. Bioorg Med Chem Lett9:1063-6 (1999) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50076777 | |||
| n/a | |||
| Name | BDBM50076777 | ||
| Synonyms: | 9-(2-Bromo-4,6-dimethoxy-phenyl)-2,8-dimethyl-6-(2-trifluoromethyl-phenyl)-9H-purine | CHEMBL10142 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H18BrF3N4O2 | ||
| Mol. Mass. | 507.303 | ||
| SMILES | COc1cc(Br)c(c(OC)c1)-n1c(C)nc2c(nc(C)nc12)-c1ccccc1C(F)(F)F |(10.58,-12.06,;11.63,-10.93,;11.18,-9.46,;9.67,-9.12,;9.22,-7.64,;7.73,-7.29,;10.27,-6.52,;11.77,-6.86,;12.82,-5.72,;14.33,-6.07,;12.23,-8.33,;9.81,-5.06,;10.71,-3.81,;12.25,-3.81,;9.8,-2.57,;8.34,-3.04,;7.01,-2.27,;5.67,-3.04,;5.67,-4.58,;4.32,-5.37,;7.01,-5.35,;8.34,-4.58,;7.01,-.73,;8.34,.04,;8.34,1.59,;7.01,2.36,;5.68,1.59,;5.68,.04,;4.32,-.75,;5.12,-2.08,;2.99,-1.52,;3.55,.6,)| | ||
| Structure | 
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