| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Corticotropin-releasing factor receptor 1 |
|---|
| Ligand | BDBM50076782 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_50977 |
|---|
| Ki | 2±n/a nM |
|---|
| Citation |  Cocuzza, AJ; Chidester, DR; Culp, S; Fitzgerald, L; Gilligan, P Use of the Suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists. Bioorg Med Chem Lett9:1063-6 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Corticotropin-releasing factor receptor 1 |
|---|
| Name: | Corticotropin-releasing factor receptor 1 |
|---|
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 50744.31 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P34998 |
|---|
| Residue: | 444 |
|---|
| Sequence: | MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
|
|
|
|---|
| BDBM50076782 |
|---|
| n/a |
|---|
| Name | BDBM50076782 |
|---|
| Synonyms: | CHEMBL10154 | N-Cyclopropylmethyl-N-ethyl-2,5-dimethyl-N'-(2,4,6-trichloro-phenyl)-pyrimidine-4,6-diamine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H21Cl3N4 |
|---|
| Mol. Mass. | 399.745 |
|---|
| SMILES | CCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C |
|---|
| Structure | 
|
|---|
Search and Browse
