Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Corticotropin-releasing factor receptor 1 | ||
Ligand | BDBM50074458 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_50977 | ||
Ki | 3.5±n/a nM | ||
Citation | Cocuzza, AJ; Chidester, DR; Culp, S; Fitzgerald, L; Gilligan, P Use of the Suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists. Bioorg Med Chem Lett9:1063-6 (1999) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Corticotropin-releasing factor receptor 1 | |||
Name: | Corticotropin-releasing factor receptor 1 | ||
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 50744.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34998 | ||
Residue: | 444 | ||
Sequence: |
| ||
BDBM50074458 | |||
n/a | |||
Name | BDBM50074458 | ||
Synonyms: | CHEMBL9633 | [3-(2-Bromo-4,6-dimethoxy-phenyl)-5-methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-butyl-ethyl-amine | ||
Type | Small organic molecule | ||
Emp. Form. | C19H25BrN6O2 | ||
Mol. Mass. | 449.345 | ||
SMILES | CCCCN(CC)c1nc(C)nc2n(nnc12)-c1c(Br)cc(OC)cc1OC |(13.26,-.73,;11.93,.04,;10.59,-.73,;9.26,.02,;7.91,-.75,;6.58,.02,;5.24,-.76,;7.92,-2.29,;6.59,-3.06,;6.59,-4.61,;5.24,-5.38,;7.92,-5.38,;9.26,-4.6,;10.73,-5.08,;11.64,-3.83,;10.73,-2.58,;9.26,-3.06,;11.2,-6.55,;12.7,-6.86,;13.73,-5.71,;13.19,-8.31,;12.16,-9.47,;12.63,-10.95,;11.6,-12.09,;10.64,-9.15,;10.17,-7.69,;8.66,-7.37,;7.63,-8.52,)| | ||
Structure |