Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50076901 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_51119 (CHEMBL665732) | ||
| Ki | 9.2±n/a nM | ||
| Citation |  Beck, JP; Curry, MA; Chorvat, RJ; Fitzgerald, LW; Gilligan, PJ; Zaczek, R; Trainor, GL Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists. Bioorg Med Chem Lett9:1185-8 (1999) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
| ||
| BDBM50076901 | |||
| n/a | |||
| Name | BDBM50076901 | ||
| Synonyms: | 7-Diethylamino-5-methyl-3-(2,4,6-trimethyl-phenyl)-3H-thiazolo[4,5-d]pyrimidine-2-thione | CHEMBL413968 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H24N4S2 | ||
| Mol. Mass. | 372.551 | ||
| SMILES | CCN(CC)c1nc(C)nc2n(-c3c(C)cc(C)cc3C)c(=S)sc12 |(15.45,-10.38,;15.46,-11.93,;14.11,-12.7,;12.79,-11.93,;12.79,-10.39,;14.11,-14.24,;12.8,-15.01,;12.8,-16.55,;11.45,-17.32,;14.11,-17.32,;15.46,-16.55,;16.93,-17.02,;17.41,-18.47,;18.92,-18.78,;19.93,-17.63,;19.4,-20.23,;18.37,-21.39,;18.88,-22.85,;16.87,-21.07,;16.39,-19.62,;14.88,-19.3,;17.83,-15.77,;19.37,-15.77,;16.92,-14.53,;15.46,-15.01,)| | ||
| Structure | 
| ||