| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily V member 4 |
|---|
| Ligand | BDBM50521995 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1885905 (CHEMBL4387487) |
|---|
| IC50 | 1.2±n/a nM |
|---|
| Citation |  Sami, Y; Morita, M; Kubota, H; Hirabayashi, R; Seo, R; Nakagawa, N Discovery of a novel orally active TRPV4 inhibitor: Part 1. Optimization from an HTS hit. Bioorg Med Chem27:3775-3787 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transient receptor potential cation channel subfamily V member 4 |
|---|
| Name: | Transient receptor potential cation channel subfamily V member 4 |
|---|
| Synonyms: | TRPV4 | TRPV4_HUMAN | Transient receptor potential cation channel subfamily V member 4 (TRPV4) | VRL2 | VROAC |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 98290.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9HBA0 |
|---|
| Residue: | 871 |
|---|
| Sequence: | MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGP
GDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDN
KRWRKKIIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRL
TDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQT
ALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHI
VNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDS
NLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYD
LSSLDTCGEEASVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLC
AMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGV
NSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTG
TYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSC
RDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGE
TVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRV
DEVNWSHWNQNLGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDE
VVVPLDSMGNPRCDGHQQGYPRKWRTDDAPL
|
|
|
|---|
| BDBM50521995 |
|---|
| n/a |
|---|
| Name | BDBM50521995 |
|---|
| Synonyms: | CHEMBL4578182 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H31Cl2FN6OS |
|---|
| Mol. Mass. | 541.512 |
|---|
| SMILES | Cl.Cl.Cc1c(cnn1-c1ccc(F)cn1)C(=O)Nc1nc(C2CCC2)c(CCN2CCCCC2)s1 |
|---|
| Structure | 
|
|---|
Search and Browse
