Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM50077089 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_221915 |
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IC50 | 702.0±n/a nM |
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Citation | Barn, DR; Bom, A; Cottney, J; Caulfield, WL; Morphy, JR Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis. Bioorg Med Chem Lett9:1329-34 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44503.11 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
Residue: | 398 |
Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM50077089 |
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n/a |
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Name | BDBM50077089 |
Synonyms: | 4-[(S)-((2S,5R)-4-Benzo[1,3]dioxol-5-ylmethyl-2,5-dimethyl-piperazin-1-yl)-phenyl-methyl]-N,N-diethyl-benzamide | CHEMBL286053 |
Type | Small organic molecule |
Emp. Form. | C32H39N3O3 |
Mol. Mass. | 513.6704 |
SMILES | CCN(CC)C(=O)c1ccc(cc1)[C@@H](N1C[C@@H](C)N(Cc2ccc3OCOc3c2)C[C@@H]1C)c1ccccc1 |
Structure |
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